Description:
<jats:sec><jats:title>Background</jats:title><jats:p>The ATP-binding cassette transporter A1 <jats:italic>(ABCA1)</jats:italic> is likely associated with the risk of type 2 diabetes mellitus (T2DM) <jats:italic>via</jats:italic> β cell function modification, but the evidence on the association remains unclear. This study aimed to investigate the relationship between the <jats:italic>ABCA1</jats:italic> 69C&gt;T polymorphism and the risk of T2DM through a systematic review and meta-analysis.</jats:p></jats:sec><jats:sec><jats:title>Materials and Methods</jats:title><jats:p>The PubMed, Web of Science, and Embase databases were searched for qualified studies published until August 2020. Studies that included the association between the <jats:italic>ABCA1</jats:italic> 69C&gt;T polymorphism and the risk of T2DM were reviewed. The odds ratios (ORs) and 95% confidence intervals (CIs) were evaluated.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>We analyzed data from a total of 10 studies involving 17,742 patients. We found that the CC or CT genotype was associated with increased risk of T2DM than the TT genotype (OR, 1.41; 95% CI, 1.02-1.93). In the Asian population, the C allele carriers had a higher risk of T2DM than those with the TT genotype; the ORs of the CC and CT genotypes were 1.80 (95% CI, 1.21-2.68) and 1.61 (95% CI, and 1.29-2.01), respectively.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>This meta-analysis confirmed that the <jats:italic>ABCA1</jats:italic> 69C&gt;T genotype showed a decrease risk of T2DM compared to the CC or CT genotypes.</jats:p></jats:sec>