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Media type:
E-Article
Title:
Applications of liquid chromatography-mass spectrometry based metabolomics in predictive and personalized medicine
Contributor:
Zhou, Juntuo;
Zhong, Lijun
imprint:
Frontiers Media SA, 2022
Published in:Frontiers in Molecular Biosciences
Language:
Not determined
DOI:
10.3389/fmolb.2022.1049016
ISSN:
2296-889X
Origination:
Footnote:
Description:
<jats:p>Metabolomics is a fast-developing technique used in biomedical researches focusing on pathological mechanism illustration or novel biomarker development for diseases. The ability of simultaneously quantifying thousands of metabolites in samples makes metabolomics a promising technique in predictive or personalized medicine-oriented researches and applications. Liquid chromatography-mass spectrometry is the most widely employed analytical strategy for metabolomics. In this current mini-review, we provide a brief update on the recent developments and novel applications of LC-MS based metabolomics in the predictive and personalized medicine sector, such as early diagnosis, molecular phenotyping or prognostic evaluation. COVID-19 related metabolomic studies are also summarized. We also discuss the prospects of metabolomics in precision medicine-oriented researches, as well as critical issues that need to be addressed when employing metabolomic strategy in clinical applications.</jats:p>