You can manage bookmarks using lists, please log in to your user account for this.
Media type:
E-Article
Title:
Distribution and inter-regional relationship of amyloid-beta plaque deposition in a 5xFAD mouse model of Alzheimer’s disease
Contributor:
Tsui, Ka Chun;
Roy, Jaydeep;
Chau, Sze Chun;
Wong, Kah Hui;
Shi, Lei;
Poon, Chi Him;
Wang, Yingyi;
Strekalova, Tatyana;
Aquili, Luca;
Chang, Raymond Chuen-Chung;
Fung, Man-Lung;
Song, You-qiang;
Lim, Lee Wei
imprint:
Frontiers Media SA, 2022
Published in:Frontiers in Aging Neuroscience
Language:
Not determined
DOI:
10.3389/fnagi.2022.964336
ISSN:
1663-4365
Origination:
Footnote:
Description:
<jats:p>Alzheimer’s disease (AD) is the most common form of dementia. Although previous studies have selectively investigated the localization of amyloid-beta (Aβ) deposition in certain brain regions, a comprehensive characterization of the rostro-caudal distribution of Aβ plaques in the brain and their inter-regional correlation remain unexplored. Our results demonstrated remarkable working and spatial memory deficits in 9-month-old 5xFAD mice compared to wildtype mice. High Aβ plaque load was detected in the somatosensory cortex, piriform cortex, thalamus, and dorsal/ventral hippocampus; moderate levels of Aβ plaques were observed in the motor cortex, orbital cortex, visual cortex, and retrosplenial dysgranular cortex; and low levels of Aβ plaques were located in the amygdala, and the cerebellum; but no Aβ plaques were found in the hypothalamus, raphe nuclei, vestibular nucleus, and cuneate nucleus. Interestingly, the deposition of Aβ plaques was positively associated with brain inter-regions including the prefrontal cortex, somatosensory cortex, medial amygdala, thalamus, and the hippocampus. In conclusion, this study provides a comprehensive morphological profile of Aβ deposition in the brain and its inter-regional correlation. This suggests an association between Aβ plaque deposition and specific brain regions in AD pathogenesis.</jats:p>