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Albano, Francesco; Vecchio, Eleonora; Renna, Maurizio; Iaccino, Enrico; Mimmi, Selena; Caiazza, Carmen; Arcucci, Alessandro; Avagliano, Angelica; Pagliara, Valentina; Donato, Giuseppe; Palmieri, Camillo; Mallardo, Massimo; Quinto, Ileana; Fiume, Giuseppe

Insights into Thymus Development and Viral Thymic Infections

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  • Media type: E-Article
  • Title: Insights into Thymus Development and Viral Thymic Infections
  • Contributor: Albano, Francesco; Vecchio, Eleonora; Renna, Maurizio; Iaccino, Enrico; Mimmi, Selena; Caiazza, Carmen; Arcucci, Alessandro; Avagliano, Angelica; Pagliara, Valentina; Donato, Giuseppe; Palmieri, Camillo; Mallardo, Massimo; Quinto, Ileana; Fiume, Giuseppe
  • imprint: MDPI AG, 2019
  • Published in: Viruses
  • Language: English
  • DOI: 10.3390/v11090836
  • ISSN: 1999-4915
  • Keywords: Virology ; Infectious Diseases
  • Origination:
  • Footnote:
  • Description: <jats:p>T-cell development in the thymus is a complex and highly regulated process, involving a wide variety of cells and molecules which orchestrate thymocyte maturation into either CD4+ or CD8+ single-positive (SP) T cells. Here, we briefly review the process regulating T-cell differentiation, which includes the latest advances in this field. In particular, we highlight how, starting from a pool of hematopoietic stem cells in the bone marrow, the sequential action of transcriptional factors and cytokines dictates the proliferation, restriction of lineage potential, T-cell antigen receptors (TCR) gene rearrangements, and selection events on the T-cell progenitors, ultimately leading to the generation of mature T cells. Moreover, this review discusses paradigmatic examples of viral infections affecting the thymus that, by inducing functional changes within this lymphoid gland, consequently influence the behavior of peripheral mature T-lymphocytes.</jats:p>
  • Access State: Open Access