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Rocchigiani, Angela Maria; Ferretti, Luca; Ledda, Alice; Di Nardo, Antonello; Floris, Matteo; Bonelli, Piero; Loi, Federica; Idda, Maria Laura; Angioi, Pier Paolo; Zinellu, Susanna; Fiori, Mariangela Stefania; Bechere, Roberto; Capitta, Paola; Coccollone, Annamaria; Coradduzza, Elisabetta; Dettori, Maria Antonietta; Fattaccio, Maria Caterina; Gallisai, Elena; Maestrale, Caterina; Manunta, Daniela; Pedditzi, Aureliana; Piredda, Ivana; Palmas, Bruna; Salza, Sara; [...]

Origin, Genetic Variation and Molecular Epidemiology of SARS-CoV-2 Strains Circulating in Sardinia (Italy) during the First and Second COVID-19 Epidemic Waves

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  • Media type: E-Article
  • Title: Origin, Genetic Variation and Molecular Epidemiology of SARS-CoV-2 Strains Circulating in Sardinia (Italy) during the First and Second COVID-19 Epidemic Waves
  • Contributor: Rocchigiani, Angela Maria; Ferretti, Luca; Ledda, Alice; Di Nardo, Antonello; Floris, Matteo; Bonelli, Piero; Loi, Federica; Idda, Maria Laura; Angioi, Pier Paolo; Zinellu, Susanna; Fiori, Mariangela Stefania; Bechere, Roberto; Capitta, Paola; Coccollone, Annamaria; Coradduzza, Elisabetta; Dettori, Maria Antonietta; Fattaccio, Maria Caterina; Gallisai, Elena; Maestrale, Caterina; Manunta, Daniela; Pedditzi, Aureliana; Piredda, Ivana; Palmas, Bruna; Salza, Sara; [...]
  • Published: MDPI AG, 2023
  • Published in: Viruses, 15 (2023) 2, Seite 277
  • Language: English
  • DOI: 10.3390/v15020277
  • ISSN: 1999-4915
  • Origination:
  • Footnote:
  • Description: Understanding how geography and human mobility shape the patterns and spread of infectious diseases such as COVID-19 is key to control future epidemics. An interesting example is provided by the second wave of the COVID-19 epidemic in Europe, which was facilitated by the intense movement of tourists around the Mediterranean coast in summer 2020. The Italian island of Sardinia is a major tourist destination and is widely believed to be the origin of the second Italian wave. In this study, we characterize the genetic variation among SARS-CoV-2 strains circulating in northern Sardinia during the first and second Italian waves using both Illumina and Oxford Nanopore Technologies Next Generation Sequencing methods. Most viruses were placed into a single clade, implying that despite substantial virus inflow, most outbreaks did not spread widely. The second epidemic wave on the island was actually driven by local transmission of a single B.1.177 subclade. Phylogeographic analyses further suggest that those viral strains circulating on the island were not a relevant source for the second epidemic wave in Italy. This result, however, does not rule out the possibility of intense mixing and transmission of the virus among tourists as a major contributor to the second Italian wave.
  • Access State: Open Access