> Details

Favole, Alessandra; Testori, Camilla; Bergagna, Stefania; Gennero, Maria Silvia; Ingravalle, Francesco; Costa, Barbara; Barresi, Sara; Curti, Piercarlo; Barberis, Francesco; Ganio, Sandra; Orusa, Riccardo; Vallino Costassa, Elena; Berrone, Elena; Vernè, Marco; Scaglia, Massimo; Palmitessa, Claudia; Gallo, Marina; Tessarolo, Carlotta; Pederiva, Sabina; Ferrari, Alessio; Lorenzi, Valentina; Fusi, Francesca; Brunelli, Laura; Pastorelli, Roberta; [...]

Brain-Derived Neurotrophic Factor, Kynurenine Pathway, and Lipid-Profiling Alterations as Potential Animal Welfare Indicators in Dairy Cattle

Reference
management

Bookmarks

Remove from
bookmarks

Share this on Whatsapp

Close

Bookmarks



You can manage bookmarks using lists, please log in to your user account for this.
  • Media type: E-Article
  • Title: Brain-Derived Neurotrophic Factor, Kynurenine Pathway, and Lipid-Profiling Alterations as Potential Animal Welfare Indicators in Dairy Cattle
  • Contributor: Favole, Alessandra; Testori, Camilla; Bergagna, Stefania; Gennero, Maria Silvia; Ingravalle, Francesco; Costa, Barbara; Barresi, Sara; Curti, Piercarlo; Barberis, Francesco; Ganio, Sandra; Orusa, Riccardo; Vallino Costassa, Elena; Berrone, Elena; Vernè, Marco; Scaglia, Massimo; Palmitessa, Claudia; Gallo, Marina; Tessarolo, Carlotta; Pederiva, Sabina; Ferrari, Alessio; Lorenzi, Valentina; Fusi, Francesca; Brunelli, Laura; Pastorelli, Roberta; [...]
  • Published: MDPI AG, 2023
  • Published in: Animals, 13 (2023) 7, Seite 1167
  • Language: English
  • DOI: 10.3390/ani13071167
  • ISSN: 2076-2615
  • Keywords: General Veterinary ; Animal Science and Zoology
  • Origination:
  • Footnote:
  • Description: Complete animal welfare evaluation in intensive farming is challenging. With this study, we investigate new biomarkers for animal physical and mental health by comparing plasma expression of biochemical indicators in dairy cows reared in three different systems: (A) semi-intensive free-stall, (B) non-intensive tie-stall, and (C) intensive free-stall. Additionally, protein levels of mature brain-derived neurotrophic factor (mBDNF) and its precursor form (proBDNF) and indoleamine 2,3-dioxygenase (IDO1) specific activity were evaluated in brain samples collected from 12 cattle culled between 73 and 138 months of age. Alterations in plasma lipid composition and in the kynurenine pathway of tryptophan metabolism were observed in the tie-stall-reared animals. The total plasma BDNF concentration was higher in tie-stall group compared to the two free-housing groups. Brain analysis of the tie-stall animals revealed a different mBDNF/proBDNF ratio, with a higher level of proBDNF (p < 0.001). Our data are similar to previous studies on animal models of depression, which reported that inhibition of the conversion of proBDNF in its mature form and/or elevated peripheral kynurenine pathway activation may underlie cerebral biochemical changes and induce depressive-like state behavior in animals.
  • Access State: Open Access