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Media type:
E-Article
Title:
Beyond the Edge of Hypomethylating Agents: Novel Combination Strategies for Older Adults with Advanced MDS and AML
Contributor:
Kubasch, Anne Sophie;
Platzbecker, Uwe
Published:
MDPI AG, 2018
Published in:
Cancers, 10 (2018) 6, Seite 158
Language:
English
DOI:
10.3390/cancers10060158
ISSN:
2072-6694
Origination:
Footnote:
Description:
Higher-risk myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) of the elderly exhibit several commonalities, including first line treatment with hypomethylating agents (HMA) like azacitidine (AZA) or decitabine (DAC). Until today, response to treatment occurs in less than 50 percent of patients, and is often short-lived. Moreover, patients failing HMA have a dismal prognosis. Current developments include combinations of HMA with novel drugs targeting epigenetic or immunomodulatory pathways. Other efforts focus on the prevention of resistance to HMA using checkpoint inhibitors to enhance immune attack. This review focuses on recent advances in the field of HMA-based front-line therapies in elderly patients with myeloid diseases.