> Details

Zhang, Jiang; Teng, Xinzhi; Lam, Saikit; Sun, Jiachen; Cheung, Andy Lai-Yin; Ng, Sherry Chor-Yi; Lee, Francis Kar-Ho; Au, Kwok-Hung; Yip, Celia Wai-Yi; Lee, Victor Ho-Fun; Lin, Zhongshi; Liang, Yongyi; Yang, Ruijie; Han, Ying; Zhang, Yuanpeng; Kong, Feng-Ming (Spring); Cai, Jing

Quantitative Spatial Characterization of Lymph Node Tumor for N Stage Improvement of Nasopharyngeal Carcinoma Patients

Reference
management

Bookmarks

Remove from
bookmarks

Share this on Whatsapp

Close

Bookmarks



You can manage bookmarks using lists, please log in to your user account for this.
  • Media type: E-Article
  • Title: Quantitative Spatial Characterization of Lymph Node Tumor for N Stage Improvement of Nasopharyngeal Carcinoma Patients
  • Contributor: Zhang, Jiang; Teng, Xinzhi; Lam, Saikit; Sun, Jiachen; Cheung, Andy Lai-Yin; Ng, Sherry Chor-Yi; Lee, Francis Kar-Ho; Au, Kwok-Hung; Yip, Celia Wai-Yi; Lee, Victor Ho-Fun; Lin, Zhongshi; Liang, Yongyi; Yang, Ruijie; Han, Ying; Zhang, Yuanpeng; Kong, Feng-Ming (Spring); Cai, Jing
  • imprint: MDPI AG, 2022
  • Published in: Cancers
  • Language: English
  • DOI: 10.3390/cancers15010230
  • ISSN: 2072-6694
  • Keywords: Cancer Research ; Oncology
  • Origination:
  • Footnote:
  • Description: <jats:p>This study aims to investigate the feasibility of improving the prognosis stratification of the N staging system of Nasopharyngeal Carcinoma (NPC) from quantitative spatial characterizations of metastatic lymph node (LN) for NPC in a multi-institutional setting. A total of 194 and 284 NPC patients were included from two local hospitals as the discovery and validation cohort. Spatial relationships between LN and the surrounding organs were quantified by both distance and angle histograms, followed by principal component analysis. Independent prognostic factors were identified and combined with the N stage into a new prognostic index by univariate and multivariate Cox regressions on disease-free survival (DFS). The new three-class risk stratification based on the constructed prognostic index demonstrated superior cross-institutional performance in DFS. The hazard ratios of the high-risk to low-risk group were 9.07 (p &lt; 0.001) and 4.02 (p &lt; 0.001) on training and validation, respectively, compared with 5.19 (p &lt; 0.001) and 1.82 (p = 0.171) of N3 to N1. Our spatial characterizations of lymph node tumor anatomy improved the existing N-stage in NPC prognosis. Our quantitative approach may facilitate the discovery of new anatomical characteristics to improve patient staging in other diseases.</jats:p>
  • Access State: Open Access