> Details

Jannusch, Kai; Bittner, Ann-Kathrin; Bruckmann, Nils Martin; Morawitz, Janna; Stieglitz, Cleo; Dietzel, Frederic; Quick, Harald H.; Baba, Hideo A.; Herrmann, Ken; Umutlu, Lale; Antoch, Gerald; Kirchner, Julian; Kasimir-Bauer, Sabine; Hoffmann, Oliver

Correlation between Imaging Markers Derived from PET/MRI and Invasive Acquired Biomarkers in Newly Diagnosed Breast Cancer

Reference
management

Bookmarks

Remove from
bookmarks

Share this on Whatsapp

Close

Bookmarks



You can manage bookmarks using lists, please log in to your user account for this.
  • Media type: E-Article
  • Title: Correlation between Imaging Markers Derived from PET/MRI and Invasive Acquired Biomarkers in Newly Diagnosed Breast Cancer
  • Contributor: Jannusch, Kai; Bittner, Ann-Kathrin; Bruckmann, Nils Martin; Morawitz, Janna; Stieglitz, Cleo; Dietzel, Frederic; Quick, Harald H.; Baba, Hideo A.; Herrmann, Ken; Umutlu, Lale; Antoch, Gerald; Kirchner, Julian; Kasimir-Bauer, Sabine; Hoffmann, Oliver
  • Published: MDPI AG, 2023
  • Published in: Cancers, 15 (2023) 6, Seite 1651
  • Language: English
  • DOI: 10.3390/cancers15061651
  • ISSN: 2072-6694
  • Keywords: Cancer Research ; Oncology
  • Origination:
  • Footnote:
  • Description: <jats:p>Purpose: Evaluate the diagnostic potential of [18F]FDG-PET/MRI data compared with invasive acquired biomarkers in newly diagnosed early breast cancer (BC). Methods: Altogether 169 women with newly diagnosed BC were included. All underwent a breast- and whole-body [18F]FDG-PET/MRI for initial staging. A tumor-adapted volume of interest was placed in the primaries and defined bone regions on each standard uptake value (SUV)/apparent diffusion coefficient (ADC) dataset. Immunohistochemical markers, molecular subtype, tumor grading, and disseminated tumor cells (DTCs) of each patient were assessed after ultrasound-guided biopsy of the primaries and bone marrow (BM) aspiration. Correlation analysis and group comparisons were assessed. Results: A significant inverse correlation of estrogen-receptor (ER) expression and progesterone-receptor (PR) expression towards SUVmax was found (ER: r = 0.27, p &lt; 0.01; PR: r = 0.19, p &lt; 0.05). HER2-receptor expression showed no significant correlation towards SUV and ADC values. A significant positive correlation between Ki67 and SUVmax and SUVmean (r = 0.42 p &lt; 0.01; r = 0.19 p &lt; 0.05) was shown. Tumor grading significantly correlated with SUVmax and SUVmean (ρ = 0.36 and ρ = 0.39, both p’s &lt; 0.01). There were no group differences between SUV/ADC values of DTC-positive/-negative patients. Conclusions: [18F]FDG-PET/MRI may give a first impression of BC-receptor status and BC-tumor biology during initial staging by measuring glucose metabolism but cannot distinguish between DTC-positive/-negative patients and replace biopsy.</jats:p>
  • Access State: Open Access