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Media type:
E-Article
Title:
Sinusoidal Obstruction Syndrome Following Myeloablative Therapy and Tranexamic Acid Treatment for Hemorrhage in Two Patients with Neuroblastoma
Contributor:
Zirngibl, Felix;
Flemmig, Carina;
Lang, Peter;
Künkele, Annette;
Eggert, Angelika;
Schulte, Johannes H.;
Deubzer, Hedwig E.
Published:
MDPI AG, 2020
Published in:
Children, 7 (2020) 11, Seite 198
Language:
English
DOI:
10.3390/children7110198
ISSN:
2227-9067
Origination:
Footnote:
Description:
Adverse thromboembolic events following administration of the anti-fibrinolytic agent tranexamic acid (TA), used to prevent/treat excessive blood loss, are rare. We present the clinical course of two young patients (22 and 56 months) receiving busulfan/melphalan (Bu/Mel) high-dose chemotherapy with autologous hematopoietic stem cell transplantation (HSCT) to treat high-risk neuroblastoma, who developed hepatic sinusoidal obstruction syndrome (SOS) within 48 h after systemic TA treatment for a hemodynamically relevant hemorrhage. Defibrotide treatment resolved hepatic SOS, but the short time between TA administration and SOS onset suggests a causal association.