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Media type:
E-Article
Title:
Gram-Negative Flagella Glycosylation
Contributor:
Merino, Susana;
Tomás, Juan
Published:
MDPI AG, 2014
Published in:
International Journal of Molecular Sciences, 15 (2014) 2, Seite 2840-2857
Language:
English
DOI:
10.3390/ijms15022840
ISSN:
1422-0067
Origination:
Footnote:
Description:
Protein glycosylation had been considered as an eccentricity of a few bacteria. However, through advances in analytical methods and genome sequencing, it is now established that bacteria possess both N-linked and O-linked glycosylation pathways. Both glycosylation pathways can modify multiple proteins, flagellins from Archaea and Eubacteria being one of these. Flagella O-glycosylation has been demonstrated in many polar flagellins from Gram-negative bacteria and in only the Gram-positive genera Clostridium and Listeria. Furthermore, O-glycosylation has also been demonstrated in a limited number of lateral flagellins. In this work, we revised the current advances in flagellar glycosylation from Gram-negative bacteria, focusing on the structural diversity of glycans, the O-linked pathway and the biological function of flagella glycosylation.