• Media type: E-Article
  • Title: Gram-Negative Flagella Glycosylation
  • Contributor: Merino, Susana; Tomás, Juan
  • Published: MDPI AG, 2014
  • Published in: International Journal of Molecular Sciences, 15 (2014) 2, Seite 2840-2857
  • Language: English
  • DOI: 10.3390/ijms15022840
  • ISSN: 1422-0067
  • Origination:
  • Footnote:
  • Description: Protein glycosylation had been considered as an eccentricity of a few bacteria. However, through advances in analytical methods and genome sequencing, it is now established that bacteria possess both N-linked and O-linked glycosylation pathways. Both glycosylation pathways can modify multiple proteins, flagellins from Archaea and Eubacteria being one of these. Flagella O-glycosylation has been demonstrated in many polar flagellins from Gram-negative bacteria and in only the Gram-positive genera Clostridium and Listeria. Furthermore, O-glycosylation has also been demonstrated in a limited number of lateral flagellins. In this work, we revised the current advances in flagellar glycosylation from Gram-negative bacteria, focusing on the structural diversity of glycans, the O-linked pathway and the biological function of flagella glycosylation.
  • Access State: Open Access