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Media type:
E-Article
Title:
Effects of Luteolin and Quercetin in Combination with Some Conventional Antibiotics against Methicillin-Resistant Staphylococcus aureus
Contributor:
Usman Amin, Muhammad;
Khurram, Muhammad;
Khan, Taj;
Faidah, Hani;
Ullah Shah, Zia;
Ur Rahman, Shafiq;
Haseeb, Abdul;
Ilyas, Muhammad;
Ullah, Naseem;
Umar Khayam, Sahibzada;
Iriti, Marcello
Published:
MDPI AG, 2016
Published in:
International Journal of Molecular Sciences, 17 (2016) 11, Seite 1947
Language:
English
DOI:
10.3390/ijms17111947
ISSN:
1422-0067
Origination:
Footnote:
Description:
The present study was designed to evaluate the effects of flavonoids luteolin (L) and quercetin + luteolin (Q + L) in combination with commonly used antibacterial agents against methicillin-resistant Staphylococcus aureus (MRSA) clinical isolates and S. aureus (ATCC 43300). Minimum inhibitory concentrations (MICs) of L and Q + L, as well as the MICs of flavonoids in combination with antibiotics were determined and results showed an increased activity of flavonoids with antibiotics. The synergistic, additive, or antagonistic relationships between flavonoids (L and Q + L) and antibiotics were also evaluated, and additive and synergistic effects were observed for some antibiotic + flavonoid combinations. In addition, some combinations were also found to damage the bacterial cytoplasmic membrane, as assessed through potassium leakage assay. The effects of flavonoids and flavonoids + antibiotics on mecA gene mutations were also tested, and no functional variation was detected in the coding region.