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Media type:
E-Article
Title:
Multiple Sclerosis Treatment and Melanoma Development
Contributor:
Carbone, Maria Luigia;
Lacal, Pedro Miguel;
Messinese, Serena;
De Giglio, Laura;
Pozzilli, Carlo;
Persechino, Severino;
Mazzanti, Cinzia;
Failla, Cristina Maria;
Pagnanelli, Gianluca
Published:
MDPI AG, 2020
Published in:
International Journal of Molecular Sciences, 21 (2020) 8, Seite 2950
Language:
English
DOI:
10.3390/ijms21082950
ISSN:
1422-0067
Origination:
Footnote:
Description:
Therapy of multiple sclerosis (MS) with disease-modifying agents such as natalizumab or fingolimod has been associated with the development of cutaneous melanoma. Here we briefly revise literature data and report of a case of a 48-year old woman who developed a melanoma and several atypical naevi after sub sequential treatment with natalizumab (1 year) and fingolimod (7 years). By immunohistochemistry we observed the presence of T cells and leukocyte infiltration as well as of vascular endothelial growth factor (VEGF)-A expression in the patient melanoma biopsy. Then, we analyzed proliferation, migration and VEGF-A expression in three melanoma cell lines and found out that both natalizumab and fingolimod inhibited tumor cell proliferation but promoted or blocked cell migration depending on the cell line examined. VEGF-A secretion was augmented in one melanoma cell line only after fingolimod treatment. In conclusion, our in vitro data do not support the hypothesis of a direct action of natalizumab or fingolimod on melanoma progression but acting on the tumor microenvironment these treatments could indirectly favor melanoma evolution.