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Media type:
E-Article
Title:
NF-κB and Its Role in Checkpoint Control
Contributor:
Betzler, Annika C.;
Theodoraki, Marie-Nicole;
Schuler, Patrick J.;
Döscher, Johannes;
Laban, Simon;
Hoffmann, Thomas K.;
Brunner, Cornelia
imprint:
MDPI AG, 2020
Published in:International Journal of Molecular Sciences
Language:
English
DOI:
10.3390/ijms21113949
ISSN:
1422-0067
Origination:
Footnote:
Description:
<jats:p>Nuclear factor-κB (NF-κB) has been described as one of the most important molecules linking inflammation to cancer. More recently, it has become clear that NF-κB is also involved in the regulation of immune checkpoint expression. Therapeutic approaches targeting immune checkpoint molecules, enabling the immune system to initiate immune responses against tumor cells, constitute a key breakthrough in cancer treatment. This review discusses recent evidence for an association of NF-κB and immune checkpoint expression and examines the therapeutic potential of inhibitors targeting either NF-κB directly or molecules involved in NF-κB regulation in combination with immune checkpoint blockade.</jats:p>