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Media type:
E-Article
Title:
The Role of Sirtuin 6 in the Deacetylation of Histone Proteins as a Factor in the Progression of Neoplastic Disease
Contributor:
Baran, Marzena;
Miziak, Paulina;
Stepulak, Andrzej;
Cybulski, Marek
Published:
MDPI AG, 2023
Published in:
International Journal of Molecular Sciences, 25 (2023) 1, Seite 497
Language:
English
DOI:
10.3390/ijms25010497
ISSN:
1422-0067
Origination:
Footnote:
Description:
SIRT6 is a nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase, predominantly located in the nucleus, that is involved in the processes of histone modification, DNA repair, cell cycle regulation, and apoptosis. Disturbances in SIRT6 expression levels have been observed in the development and progression of various types of cancer. Therefore, it is important to better understand the role of SIRT6 in biochemical pathways and assign it specific biological functions. This review aims to summarize the role of SIRT6 in carcinogenesis and tumor development. A better understanding of the factors influencing SIRT6 expression and its biological role in carcinogenesis may help to develop novel anti-cancer therapeutic strategies. Moreover, we discuss the anti-cancer effects and mechanism of action of small molecule SIRT6 modulators (both activators and inhibitors) in different types of cancer.