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Constantinescu, Sorin; Niculescu, Adelina-Gabriela; Hudiță, Ariana; Grumezescu, Valentina; Rădulescu, Dragoș; Bîrcă, Alexandra Cătălina; Irimiciuc, Stefan Andrei; Gherasim, Oana; Holban, Alina Maria; Gălățeanu, Bianca; Oprea, Ovidiu Cristian; Ficai, Anton; Vasile, Bogdan Ștefan; Grumezescu, Alexandru Mihai; Bolocan, Alexandra; Rădulescu, Radu

Silver/Graphene Oxide Nanostructured Coatings for Modulating the Microbial Susceptibility of Fixation Devices Used in Knee Surgery

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  • Media type: E-Article
  • Title: Silver/Graphene Oxide Nanostructured Coatings for Modulating the Microbial Susceptibility of Fixation Devices Used in Knee Surgery
  • Contributor: Constantinescu, Sorin; Niculescu, Adelina-Gabriela; Hudiță, Ariana; Grumezescu, Valentina; Rădulescu, Dragoș; Bîrcă, Alexandra Cătălina; Irimiciuc, Stefan Andrei; Gherasim, Oana; Holban, Alina Maria; Gălățeanu, Bianca; Oprea, Ovidiu Cristian; Ficai, Anton; Vasile, Bogdan Ștefan; Grumezescu, Alexandru Mihai; Bolocan, Alexandra; Rădulescu, Radu
  • Published: MDPI AG, 2023
  • Published in: International Journal of Molecular Sciences, 25 (2023) 1, Seite 246
  • Language: English
  • DOI: 10.3390/ijms25010246
  • ISSN: 1422-0067
  • Keywords: Inorganic Chemistry ; Organic Chemistry ; Physical and Theoretical Chemistry ; Computer Science Applications ; Spectroscopy ; Molecular Biology ; General Medicine ; Catalysis
  • Origination:
  • Footnote:
  • Description: <jats:p>Exploring silver-based and carbon-based nanomaterials’ excellent intrinsic antipathogenic effects represents an attractive alternative for fabricating anti-infective formulations. Using chemical synthesis protocols, stearate-conjugated silver (Ag@C18) nanoparticles and graphene oxide nanosheets (nGOs) were herein obtained and investigated in terms of composition and microstructure. Scanning electron microscopy (SEM) and transmission electron microscopy (TEM) characterizations revealed the formation of nanomaterials with desirable physical properties, while X-ray diffraction (XRD) analyses confirmed the high purity of synthesized nanomaterials. Further, laser-processed Ag@C18-nGO coatings were developed, optimized, and evaluated in terms of biological and microbiological outcomes. The highly biocompatible Ag@C18-nGO nanostructured coatings proved suitable candidates for the local modulation of biofilm-associated periprosthetic infections.</jats:p>
  • Access State: Open Access