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Media type:
E-Article
Title:
Sudden Unexpected Death Caused by Cardiac Metastasization from Histiocytic Sarcoma
Contributor:
Feola, Alessandro;
Ciamarra, Paola;
De Simone, Mariavictoria;
Carfora, Anna;
Mansueto, Gelsomina;
Campobasso, Carlo Pietro
Published:
MDPI AG, 2021
Published in:
International Journal of Environmental Research and Public Health, 18 (2021) 24, Seite 12911
Language:
English
DOI:
10.3390/ijerph182412911
ISSN:
1660-4601
Origination:
Footnote:
Description:
Background: Haematological malignancies, such as lymphoma and leukaemia, can have a variety of clinical manifestations. The most frequent cause of death from haematological malignancies is multiple organ failure due to neoplastic organ infiltration and/or septic shock. Histiocytic sarcoma (HS) is a rare malignant nodal or extranodal tumour with histiocytic immunophenotype that originates from a lymphohematopoietic precursor. The patients with HS usually have a poor prognosis due to its aggressive clinical behaviour. Rare cases of undiagnosed sudden HS death have been described in the literature. Methods: A forensic autopsy of a 46-year-old white male who died at home suddenly and unexpectedly without warning conditions or known diseases. Gross analysis, histology and toxicology were also performed. Results: The diagnosis of HS of the ileum with secondary nodal and cardiac metastatization was made. Conclusions: A prompt diagnosis of HS in life is paramount because it can make a difference in prognostic outcomes.