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Graf, Christiana; Mondorf, Antonia; Knop, Viola; Peiffer, Kai-Henrik; Dietz, Julia; Friess, Julia; Wedemeyer, Heiner; Buggisch, Peter; Mauss, Stefan; Berg, Thomas; Rausch, Michael; Sprinzl, Martin; Klinker, Hartwig; Hinrichsen, Holger; Bronowicki, Jean-Pierre; Haag, Sebastian; Hüppe, Dietrich; Lutz, Thomas; Poynard, Thierry; Zeuzem, Stefan; Friedrich-Rust, Mireen; Sarrazin, Christoph; Vermehren, Johannes

Evaluation of Point Shear Wave Elastography Using Acoustic Radiation Force Impulse Imaging for Longitudinal Fibrosis Assessment in Patients with HBeAg-Negative HBV Infection

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  • Media type: E-Article
  • Title: Evaluation of Point Shear Wave Elastography Using Acoustic Radiation Force Impulse Imaging for Longitudinal Fibrosis Assessment in Patients with HBeAg-Negative HBV Infection
  • Contributor: Graf, Christiana; Mondorf, Antonia; Knop, Viola; Peiffer, Kai-Henrik; Dietz, Julia; Friess, Julia; Wedemeyer, Heiner; Buggisch, Peter; Mauss, Stefan; Berg, Thomas; Rausch, Michael; Sprinzl, Martin; Klinker, Hartwig; Hinrichsen, Holger; Bronowicki, Jean-Pierre; Haag, Sebastian; Hüppe, Dietrich; Lutz, Thomas; Poynard, Thierry; Zeuzem, Stefan; Friedrich-Rust, Mireen; Sarrazin, Christoph; Vermehren, Johannes
  • Published: MDPI AG, 2019
  • Published in: Journal of Clinical Medicine, 8 (2019) 12, Seite 2101
  • Language: English
  • DOI: 10.3390/jcm8122101
  • ISSN: 2077-0383
  • Origination:
  • Footnote:
  • Description: Background: Accurate assessment of hepatic fibrosis in patients with chronic HBeAg-negative Hepatitis B is of crucial importance not only to predict the long-term clinical course, but also to evaluate antiviral therapy indication. The aim of this study was to prospectively assess the utility of point shear wave elastography (pSWE) for longitudinal non-invasive fibrosis assessment in a large cohort of untreated patients with chronic HBeAg-negative hepatitis B virus (HBV) infection. Methods: 407 consecutive patients with HBeAg-negative HBV infection who underwent pSWE, transient elastography (TE) as well as laboratory fibrosis markers, including fibrosis index based on four factors (FIB-4), aspartate to platelet ratio index (APRI) and FibroTest, on the same day were prospectively followed up for six years. Patients were classified into one of the three groups: inactive carriers (IC; HBV-DNA <2000 IU/mL and ALT <40 U/L); grey zone group 1 (GZ-1; HBV DNA <2000 IU/mL and ALT >40 U/L); grey zone group 2 (GZ-2; HBV-DNA >2000 IU/mL and ALT <40 U/L). Results: pSWE results were significantly correlated with TE (r = 0.29, p < 0.001) and APRI (r = 0.17; p = 0.005). Median pSWE values did not differ between IC, GZ-1 and GZ-2 patients (p = 0.82, p = 0.17, p = 0.34). During six years of follow-up, median pSWE and TE values did not differ significantly over time (TE: p = 0.27; pSWE: p = 0.05). Conclusion: Our data indicate that pSWE could be useful for non-invasive fibrosis assessment and follow-up in patients with HBeAg-negative chronic HBV infection.
  • Access State: Open Access