Adel, Esraa M.;
Elberry, Ahmed A.;
Abdel Aziz, Ahmed;
Naguib, Ibrahim A.;
Alghamdi, Badrah S.;
Hussein, Raghda R. S.
Comparison of the Treatment Efficacy of Rosuvastatin versus Atorvastatin Loading Prior to Percutaneous Coronary Intervention in ST-Segment Elevation Myocardial Infarction
You can manage bookmarks using lists, please log in to your user account for this.
Media type:
E-Article
Title:
Comparison of the Treatment Efficacy of Rosuvastatin versus Atorvastatin Loading Prior to Percutaneous Coronary Intervention in ST-Segment Elevation Myocardial Infarction
Contributor:
Adel, Esraa M.;
Elberry, Ahmed A.;
Abdel Aziz, Ahmed;
Naguib, Ibrahim A.;
Alghamdi, Badrah S.;
Hussein, Raghda R. S.
Published:
MDPI AG, 2022
Published in:
Journal of Clinical Medicine, 11 (2022) 17, Seite 5142
Language:
English
DOI:
10.3390/jcm11175142
ISSN:
2077-0383
Origination:
Footnote:
Description:
The aim of this study was to compare the effect of a single high-dose rosuvastatin versus atorvastatin preloading in ST-elevation myocardial infarction (STEMI) patients receiving primary percutaneous coronary intervention (PCI.) Methods: A total of 99 patients presented with STEMI and were randomly divided into three groups—a control group (n = 33) with no statin treatment, an atorvastatin group (n = 33) with a single 80 mg atorvastatin dose and the rosuvastatin group (n = 33) with a single 40 mg rosuvastatin dose in the emergency room (ER) prior to PCI. Post-interventional thrombolysis in myocardial infarction (TIMI) flow grade and corrected TIMI frame count (CTFC) were recorded, and ST-segment resolution was measured. Results: CTFC was significantly lower for the atorvastatin group (p-value < 0.01) than in the control group. A final TIMI flow grade 3 was achieved in 32 (97.0%) patients in the rosuvastatin group and 28 (84.8%) patients in the atorvastatin group compared with only 25 (75.8%) patients in the control group (p = 0.014). Peak CK-MB in the rosuvastatin group (263.2 [207.2–315.6]) and the atorvastatin group (208 [151.0–314.1]) was lower compared to that in the control group (398.4 [303.9–459.3]); p < 0.001. Conclusions: A single extensive dose of lipophilic atorvastatin prior to primary PCI in STEMI patients showed better improvement in microvascular myocardial perfusion compared to hydrophilic rosuvastatin.