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Posarelli, Chiara; Figus, Michele; Roberti, Gloria; Giammaria, Sara; Ghirelli, Giorgio; Quercioli, Pierpaolo; Micelli Ferrari, Tommaso; Pace, Vincenzo; Mastropasqua, Leonardo; Agnifili, Luca; Sacchi, Matteo; Scuderi, Gianluca; Perdicchi, Andrea; Altafini, Romeo; Uva, Maurizio; D’Andrea, Dino; Covello, Giuseppe; Maglionico, Maria Novella; Fea, Antonio Maria; Carnevale, Carmela; Oddone, Francesco

Italian Candidates for the XEN Implant: An Overview from the Glaucoma Treatment Registry (XEN-GTR)

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  • Media type: E-Article
  • Title: Italian Candidates for the XEN Implant: An Overview from the Glaucoma Treatment Registry (XEN-GTR)
  • Contributor: Posarelli, Chiara; Figus, Michele; Roberti, Gloria; Giammaria, Sara; Ghirelli, Giorgio; Quercioli, Pierpaolo; Micelli Ferrari, Tommaso; Pace, Vincenzo; Mastropasqua, Leonardo; Agnifili, Luca; Sacchi, Matteo; Scuderi, Gianluca; Perdicchi, Andrea; Altafini, Romeo; Uva, Maurizio; D’Andrea, Dino; Covello, Giuseppe; Maglionico, Maria Novella; Fea, Antonio Maria; Carnevale, Carmela; Oddone, Francesco
  • Published: MDPI AG, 2022
  • Published in: Journal of Clinical Medicine, 11 (2022) 18, Seite 5320
  • Language: English
  • DOI: 10.3390/jcm11185320
  • ISSN: 2077-0383
  • Keywords: General Medicine
  • Origination:
  • Footnote:
  • Description: Background The Italian XEN Glaucoma Treatment Registry (XEN-GTR) was created to acquire a comprehensive prospective dataset that includes the patient characteristics, intraoperative variables, and postoperative management of glaucoma patients undergoing the XEN gel stent implantation. Methods This was a prospective observational, longitudinal clinical study involving 10 centres throughout Italy. The baseline examination included a comprehensive evaluation of demographic parameters (age, sex, ethnicity, and systemic condition), specific ophthalmological parameters, and quality of life questionnaire score collection. Results The baseline data of 273 patients were analysed. The median (IQR) age was 72 (65.0 to 78.0) years. Of the 273 patients, 123 (45%) were female and 150 (55%) were male. A total of 86% of the patients had open-angle glaucoma with a mean intraocular pressure of 24 ± 6 (range 12.0–60.0) mmHg. The mean number of medications was 2.7 ± 0.9 at baseline for the patients with a prevalence of prostaglandin analogues combined with a beta-blocker and anhydrase carbonic inhibitor (31.8%). The mean scores of the NEI-VFQ 25 and GSS questionnaires were 78 ± 18 (range 26.5–100) and 85 ± 14 (range 79–93), respectively. Combined XEN/cataract surgeries were scheduled in 73.7% of the patients. The preferred place for the XEN implant was the supero-nasal quadrant (91.6%). Conclusions Observing the baseline characteristics of the typical Italian candidates for the XEN gel implant shows that they are patients affected by POAG and cataracts, with moderate to severe glaucoma damage, all of which has an impact on their quality of life.
  • Access State: Open Access