• Media type: E-Article
  • Title: In Vitro Comparison of Several Thrombus Removal Tools
  • Contributor: Pigoń, Katarzyna; Tomecka, Natalia; Korner, Dominika; Pękała, Maciej; Grzegorczyn, Sławomir; Konka, Adam; Nowalany-Kozielska, Ewa; Tomasik, Andrzej
  • Published: MDPI AG, 2023
  • Published in: Journal of Cardiovascular Development and Disease, 10 (2023) 2, Seite 69
  • Language: English
  • DOI: 10.3390/jcdd10020069
  • ISSN: 2308-3425
  • Keywords: Pharmacology (medical) ; General Pharmacology, Toxicology and Pharmaceutics
  • Origination:
  • Footnote:
  • Description: Background: Although the routine use of thrombus aspiration is not recommended, the thrombectomy technique still might be considered for a selected population of patients. Therefore, the assessment of the effectiveness of commercially available thrombectomy devices is still clinically relevant. Aim: Here, we present an in vitro comparison of several different types of catheters that can be used for thrombus aspiration or removal. Methods: Through the removal of 6 h and 24 h human blood clots in an in vitro model, four catheters were compared: the Launcher, Pronto V4, Vasco+ and the stent-retriever Catchview. The aspiration efficacy was expressed as a percentage of the initial thrombus weight. The effectiveness of the patient’s aspiration was dependent on the time of thrombus formation and was significantly higher for a thrombus formed over 24 h (58.5 ± 26.5%) than for one formed over 6 h (48.0 ± 22.5%; p < 0.001). In the presented in vitro model, Pronto V4 and Launcher showed the highest efficiency. Conclusions: Large-bore aspiration catheters were found to be more effective than narrow-bore catheters or stent-retrievers in an in vitro model of thrombus removal. The thrombus aspiration efficacy increases with longer thrombus formation times.
  • Access State: Open Access