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de Rojas, Itziar; Hernández, Isabel; Montrreal, Laura; Quintela, Inés; Calero, Miguel; Royo, Jose Luís; Huerto Vilas, Raquel; González-Pérez, Antonio; Franco-Macías, Emilio; Macías, Juan; Menéndez-González, Manuel; Frank-García, Ana; Diez-Fairen, Mónica; Lage, Carmen; García-Madrona, Sebastián; Aguilera, Nuria; García-González, Pablo; Puerta, Raquel; Sotolongo-Grau, Oscar; Alonso-Lana, Silvia; Rábano, Alberto; Arias Pastor, Alfonso; Pastor, Ana Belén; Corma-Gómez, Anaïs; [...]

Genomic Characterization of Host Factors Related to SARS-CoV-2 Infection in People with Dementia and Control Populations: The GR@ACE/DEGESCO Study

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  • Media type: E-Article
  • Title: Genomic Characterization of Host Factors Related to SARS-CoV-2 Infection in People with Dementia and Control Populations: The GR@ACE/DEGESCO Study
  • Contributor: de Rojas, Itziar; Hernández, Isabel; Montrreal, Laura; Quintela, Inés; Calero, Miguel; Royo, Jose Luís; Huerto Vilas, Raquel; González-Pérez, Antonio; Franco-Macías, Emilio; Macías, Juan; Menéndez-González, Manuel; Frank-García, Ana; Diez-Fairen, Mónica; Lage, Carmen; García-Madrona, Sebastián; Aguilera, Nuria; García-González, Pablo; Puerta, Raquel; Sotolongo-Grau, Oscar; Alonso-Lana, Silvia; Rábano, Alberto; Arias Pastor, Alfonso; Pastor, Ana Belén; Corma-Gómez, Anaïs; [...]
  • imprint: MDPI AG, 2021
  • Published in: Journal of Personalized Medicine
  • Language: English
  • DOI: 10.3390/jpm11121318
  • ISSN: 2075-4426
  • Keywords: Medicine (miscellaneous)
  • Origination:
  • Footnote:
  • Description: <jats:p>Emerging studies have suggested several chromosomal regions as potential host genetic factors involved in the susceptibility to SARS-CoV-2 infection and disease outcome. We nested a COVID-19 genome-wide association study using the GR@ACE/DEGESCO study, searching for susceptibility factors associated with COVID-19 disease. To this end, we compared 221 COVID-19 confirmed cases with 17,035 individuals in whom the COVID-19 disease status was unknown. Then, we performed a meta-analysis with the publicly available data from the COVID-19 Host Genetics Initiative. Because the APOE locus has been suggested as a potential modifier of COVID-19 disease, we added sensitivity analyses stratifying by dementia status or by disease severity. We confirmed the existence of the 3p21.31 region (LZTFL1, SLC6A20) implicated in the susceptibility to SARS-CoV-2 infection and TYK2 gene might be involved in COVID-19 severity. Nevertheless, no statistically significant association was observed in the COVID-19 fatal outcome or in the stratified analyses (dementia-only and non-dementia strata) for the APOE locus not supporting its involvement in SARS-CoV-2 pathobiology or COVID-19 prognosis.</jats:p>
  • Access State: Open Access