You can manage bookmarks using lists, please log in to your user account for this.
Media type:
E-Article
Title:
Targeting Mitochondrial Metabolism to Save the Failing Heart
Contributor:
Schenkl, Christina;
Heyne, Estelle;
Doenst, Torsten;
Schulze, Paul Christian;
Nguyen, Tien Dung
Published:
MDPI AG, 2023
Published in:
Life, 13 (2023) 4, Seite 1027
Language:
English
DOI:
10.3390/life13041027
ISSN:
2075-1729
Origination:
Footnote:
Description:
Despite considerable progress in treating cardiac disorders, the prevalence of heart failure (HF) keeps growing, making it a global medical and economic burden. HF is characterized by profound metabolic remodeling, which mostly occurs in the mitochondria. Although it is well established that the failing heart is energy-deficient, the role of mitochondria in the pathophysiology of HF extends beyond the energetic aspects. Changes in substrate oxidation, tricarboxylic acid cycle and the respiratory chain have emerged as key players in regulating myocardial energy homeostasis, Ca2+ handling, oxidative stress and inflammation. This work aims to highlight metabolic alterations in the mitochondria and their far-reaching effects on the pathophysiology of HF. Based on this knowledge, we will also discuss potential metabolic approaches to improve cardiac function.