• Media type: E-Article
  • Title: 1-Phenyl-8-[[4-(pyrrolo[1,2-a]quinoxalin-4-yl)phenyl]methyl]-1,3,8-triazaspiro[4.5]decan-4-one: Synthesis, Crystal Structure and Anti-Leukemic Activity
  • Contributor: Guillon, Jean; Savrimoutou, Solène; Rubio, Sandra; Moreau, Stéphane; Pinaud, Noël; Marchivie, Mathieu; Desplat, Vanessa
  • Published: MDPI AG, 2020
  • Published in: Molbank, 2020 (2020) 1, Seite M1113
  • Language: English
  • DOI: 10.3390/m1113
  • ISSN: 1422-8599
  • Origination:
  • Footnote:
  • Description: 1-Phenyl-8-[[4-(pyrrolo[1,2-a]quinoxalin-4-yl)phenyl]methyl]-1,3,8-triazaspiro[4.5]decan-4-one has been successfully synthesized via a multi-step pathway starting from 2-nitroaniline. Structure characterization of this original pyrrolo[1,2-a]quinoxaline derivative was achieved by FT-IR, 1H-NMR, 13C-NMR, X-Ray and HRMS spectral analysis. This title compound shows interesting cytotoxic potential against several human leukemia cell lines (K562, HL60, and U937 cells).
  • Access State: Open Access