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Perkovic-Kepeci, Sonja; Cirkovic, Andja; Milic, Natasa; Dugalic, Stefan; Stanisavljevic, Dejana; Milincic, Milos; Kostic, Konstantin; Milic, Nikola; Todorovic, Jovana; Markovic, Ksenija; Aleksic Grozdic, Natasa; Gojnic Dugalic, Miroslava

Doppler Indices of the Uterine, Umbilical and Fetal Middle Cerebral Artery in Diabetic versus Non-Diabetic Pregnancy: Systematic Review and Meta-Analysis

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  • Media type: E-Article
  • Title: Doppler Indices of the Uterine, Umbilical and Fetal Middle Cerebral Artery in Diabetic versus Non-Diabetic Pregnancy: Systematic Review and Meta-Analysis
  • Contributor: Perkovic-Kepeci, Sonja; Cirkovic, Andja; Milic, Natasa; Dugalic, Stefan; Stanisavljevic, Dejana; Milincic, Milos; Kostic, Konstantin; Milic, Nikola; Todorovic, Jovana; Markovic, Ksenija; Aleksic Grozdic, Natasa; Gojnic Dugalic, Miroslava
  • imprint: MDPI AG, 2023
  • Published in: Medicina
  • Language: English
  • DOI: 10.3390/medicina59081502
  • ISSN: 1648-9144
  • Keywords: General Medicine
  • Origination:
  • Footnote:
  • Description: <jats:p>Background and Objectives: The aim of this study was to assess the differences in Doppler indices of the uterine (Ut), umbilical (UA), and middle cerebral artery (MCA) in diabetic versus non-diabetic pregnancies by conducting a comprehensive systematic review of the literature with a meta-analysis. Materials and Methods: PubMed, Web of Science, and SCOPUS were searched for studies that measured the pulsatility index (PI), resistance index (RI), and systolic/diastolic ratio index (S/D ratio) of the umbilical artery, middle cerebral artery, and uterine artery in diabetic versus non-diabetic pregnancies. Two reviewers independently evaluated the eligibility of studies, abstracted data, and performed quality assessments according to standardized protocols. The standardized mean difference (SMD) was used as a measure of effect size. Heterogeneity was assessed using the I2 statistic. Publication bias was evaluated by means of funnel plots. Results: A total of 62 publications were included in the qualitative and 43 in quantitative analysis. The UA-RI, UtA-PI, and UtA-S/D ratios were increased in diabetic compared with non-diabetic pregnancies. Subgroup analysis showed that levels of UtA-PI were significantly higher during the third, but not during the first trimester of pregnancy in diabetic versus non-diabetic pregnancies. No differences were found for the UA-PI, UA-S/D ratio, MCA-PI, MCA-RI, MCA-S/D ratio, or UtA-RI between diabetic and non-diabetic pregnancies. Conclusions: This meta-analysis revealed the presence of hemodynamic changes in uterine and umbilical arteries, but not in the middle cerebral artery in pregnancies complicated by diabetes.</jats:p>
  • Access State: Open Access