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Yousuf, Muhammad; Khan, Haji Muhammad Shoaib; Rasool, Fatima; Khan, Kashif ur Rehman; Usman, Faisal; Ghalloo, Bilal Ahmad; Umair, Muhammad; Babalghith, Ahmad O.; Kamran, Muhammad; Aadil, Rana Muhammad; Al Jaouni, Soad K.; Selim, Samy; Korma, Sameh A.; Conte-Junior, Carlos Adam

Chemical Profiling, Formulation Development, In Vitro Evaluation and Molecular Docking of Piper nigrum Seeds Extract Loaded Emulgel for Anti-Aging

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  • Media type: E-Article
  • Title: Chemical Profiling, Formulation Development, In Vitro Evaluation and Molecular Docking of Piper nigrum Seeds Extract Loaded Emulgel for Anti-Aging
  • Contributor: Yousuf, Muhammad; Khan, Haji Muhammad Shoaib; Rasool, Fatima; Khan, Kashif ur Rehman; Usman, Faisal; Ghalloo, Bilal Ahmad; Umair, Muhammad; Babalghith, Ahmad O.; Kamran, Muhammad; Aadil, Rana Muhammad; Al Jaouni, Soad K.; Selim, Samy; Korma, Sameh A.; Conte-Junior, Carlos Adam
  • imprint: MDPI AG, 2022
  • Published in: Molecules
  • Language: English
  • DOI: 10.3390/molecules27185990
  • ISSN: 1420-3049
  • Keywords: Chemistry (miscellaneous) ; Analytical Chemistry ; Organic Chemistry ; Physical and Theoretical Chemistry ; Molecular Medicine ; Drug Discovery ; Pharmaceutical Science
  • Origination:
  • Footnote:
  • Description: <jats:p>Emulgel is a new innovatory technique for drug development permitting controlled release of active ingredients for topical administration. We report a stable emulgel of 4% Piper nigrum extract (PNE) prepared using 80% ethanol. The PNE-loaded formulation had an antioxidant activity of 84% and tyrosinase inhibition was 82%. Prepared formulation rendered spherical-shaped globules with high zeta potential (−45.5 mV) indicative of a stable system. Total phenolic contents were 58.01 mg GAE/g of dry extract whereas total flavonoid content was 52.63 mg QE/g of dry extract. Sun protection factor for PNE-loaded emulgel was 7.512 and formulation was stable without any evidence of physical and chemical changes following 90 days of storage. Gas chromatography-mass spectroscopy (GC-MS) revealed seventeen bioactive compounds in the PNE including monoterpenoids, triterpenoids, a tertiary alcohol, fatty acid esters, and phytosterols. In silico studies of GC-MS identified compounds show higher binding affinity in comparison to standard kojic acid indicating tyrosinase inhibition. It can be concluded that PNE-loaded emulgel had prominent antioxidant and tyrosinase inhibition and can be utilized as a promising topical system for anti-aging skin formulation.</jats:p>
  • Access State: Open Access