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Media type:
E-Article
Title:
Unusual Novel SnoRNA-Like RNAs in Drosophila melanogaster
Contributor:
Agrisani, Alberto;
Tafer, Hakim;
Stadler, Peter;
Furia, Maria
Published:
MDPI AG, 2015
Published in:
Non-Coding RNA, 1 (2015) 2, Seite 139-150
Language:
English
DOI:
10.3390/ncrna1020139
ISSN:
2311-553X
Origination:
Footnote:
Description:
A computational screen for novel small nucleolar RNAs in Drosophila melanogaster uncovered 15 novel snoRNAs and snoRNA-like long non-coding RNAs. In contrast to earlier surverys, the novel sequences are mostly poorly conserved and originate from unusual genomic locations. The majority derive from precurors antisense to well-known protein-coding genes, and four of the candidates are produced from exon-coding regions. Only a minority of the new sequences appears to have canonical target sites in ribosomal or small nuclear RNAs. Taken together, these evolutionary young, poorly conserved, and genomically atypical sequences point at a class of snoRNA-like transcripts with predominantly regulatory functions in the fruit fly genome.