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Jeitler, Michael; Lauche, Romy; Hohmann, Christoph; Choi, Kyung-Eun (Anna); Schneider, Nadia; Steckhan, Nico; Rathjens, Florian; Anheyer, Dennis; Paul, Anna; von Scheidt, Christel; Ostermann, Thomas; Schneider, Elisabeth; Koppold-Liebscher, Daniela; Kessler, Christian S.; Dobos, Gustav; Michalsen, Andreas; Cramer, Holger

A Randomized Controlled Trial of Fasting and Lifestyle Modification in Patients with Metabolic Syndrome: Effects on Patient-Reported Outcomes

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  • Media type: E-Article
  • Title: A Randomized Controlled Trial of Fasting and Lifestyle Modification in Patients with Metabolic Syndrome: Effects on Patient-Reported Outcomes
  • Contributor: Jeitler, Michael; Lauche, Romy; Hohmann, Christoph; Choi, Kyung-Eun (Anna); Schneider, Nadia; Steckhan, Nico; Rathjens, Florian; Anheyer, Dennis; Paul, Anna; von Scheidt, Christel; Ostermann, Thomas; Schneider, Elisabeth; Koppold-Liebscher, Daniela; Kessler, Christian S.; Dobos, Gustav; Michalsen, Andreas; Cramer, Holger
  • Published: MDPI AG, 2022
  • Published in: Nutrients, 14 (2022) 17, Seite 3559
  • Language: English
  • DOI: 10.3390/nu14173559
  • ISSN: 2072-6643
  • Origination:
  • Footnote:
  • Description: Lifestyle interventions can have a positive impact on quality of life and psychological parameters in patients with metabolic syndrome (MetS). In this randomized controlled trial, 145 participants with MetS (62.8% women; 59.7 ± 9.3 years) were randomized to (1) 5-day fasting followed by 10 weeks of lifestyle modification (F + LM; modified DASH diet, exercise, mindfulness; n = 73) or (2) 10 weeks of lifestyle modification only (LM; n = 72). Outcomes were assessed at weeks 0, 1, 12, and 24, and included quality of life (Short-Form 36 Health Survey Questionnaire, SF-36), anxiety/depression (Hospital Anxiety and Depression Scale, HADS), stress (Cohen Perceived Stress Scale, CPSS), mood (Profile of Mood States, POMS), self-efficacy (General Self-Efficacy Scale, GSE), mindfulness (Mindfulness Attention Awareness Scale, MAAS), and self-compassion (Self-Compassion Scale, SCS). At week 1, POMS depression and fatigue scores were significantly lower in F + LM compared to LM. At week 12, most self-report outcomes improved in both groups—only POMS vigor was significantly higher in F + LM than in LM. Most of the beneficial effects within the groups persisted at week 24. Fasting can induce mood-modulating effects in the short term. LM induced several positive effects on quality of life and psychological parameters in patients with MetS.
  • Access State: Open Access