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Salvador-Martín, Sara; Kaczmarczyk, Bartosz; Álvarez, Rebeca; Navas-López, Víctor Manuel; Gallego-Fernández, Carmen; Moreno-Álvarez, Ana; Solar-Boga, Alfonso; Sánchez, Cesar; Tolin, Mar; Velasco, Marta; Muñoz-Codoceo, Rosana; Rodriguez-Martinez, Alejandro; Vayo, Concepción A.; Bossacoma, Ferrán; Pujol-Muncunill, Gemma; Fobelo, María J.; Millán-Jiménez, Antonio; Magallares, Lorena; Martínez-Ojinaga, Eva; Loverdos, Inés; Eizaguirre, Francisco J.; Blanca-García, José A.; Clemente, Susana; García-Romero, Ruth; [...]

Whole Transcription Profile of Responders to Anti-TNF Drugs in Pediatric Inflammatory Bowel Disease

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  • Media type: E-Article
  • Title: Whole Transcription Profile of Responders to Anti-TNF Drugs in Pediatric Inflammatory Bowel Disease
  • Contributor: Salvador-Martín, Sara; Kaczmarczyk, Bartosz; Álvarez, Rebeca; Navas-López, Víctor Manuel; Gallego-Fernández, Carmen; Moreno-Álvarez, Ana; Solar-Boga, Alfonso; Sánchez, Cesar; Tolin, Mar; Velasco, Marta; Muñoz-Codoceo, Rosana; Rodriguez-Martinez, Alejandro; Vayo, Concepción A.; Bossacoma, Ferrán; Pujol-Muncunill, Gemma; Fobelo, María J.; Millán-Jiménez, Antonio; Magallares, Lorena; Martínez-Ojinaga, Eva; Loverdos, Inés; Eizaguirre, Francisco J.; Blanca-García, José A.; Clemente, Susana; García-Romero, Ruth; [...]
  • imprint: MDPI AG, 2021
  • Published in: Pharmaceutics
  • Language: English
  • DOI: 10.3390/pharmaceutics13010077
  • ISSN: 1999-4923
  • Keywords: Pharmaceutical Science
  • Origination:
  • Footnote:
  • Description: <jats:p>Background: Up to 30% of patients with pediatric inflammatory bowel disease (IBD) do not respond to anti-Tumor Necrosis Factor (anti-TNF) therapy. The aim of this study was to identify pharmacogenomic markers that predict early response to anti-TNF drugs in pediatric patients with IBD. Methods: An observational, longitudinal, prospective cohort study was conducted. The study population comprised 38 patients with IBD aged &lt; 18 years who started treatment with infliximab or adalimumab (29 responders and nine non-responders). Whole gene expression profiles from total RNA isolated from whole blood samples of six responders and six non-responders taken before administration of the biologic and after two weeks of therapy were analyzed using next-generation RNA sequencing. The expression of six selected genes was measured for purposes of validation in all of the 38 patients recruited using qPCR. Results: Genes were differentially expressed in non-responders and responders (32 before initiation of treatment and 44 after two weeks, Log2FC (Fold change) &gt;0.6 or &lt;−0.6 and p value &lt; 0.05). After validation, FCGR1A, FCGR1B, and GBP1 were overexpressed in non-responders two weeks after initiation of anti-TNF treatment (Log2FC 1.05, 1.21, and 1.08, respectively, p value &lt; 0.05). Conclusion: Expression of the FCGR1A, FCGR1B, and GBP1 genes is a pharmacogenomic biomarker of early response to anti-TNF agents in pediatric IBD.</jats:p>
  • Access State: Open Access