Wilhelm Romero, Krissia;
Quirós, María Isabel;
Vargas Huertas, Felipe;
Vega-Baudrit, José Roberto;
Navarro-Hoyos, Mirtha;
Araya-Sibaja, Andrea Mariela
Design of Hybrid Polymeric-Lipid Nanoparticles Using Curcumin as a Model: Preparation, Characterization, and In Vitro Evaluation of Demethoxycurcumin and Bisdemethoxycurcumin-Loaded Nanoparticles
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Media type:
E-Article
Title:
Design of Hybrid Polymeric-Lipid Nanoparticles Using Curcumin as a Model: Preparation, Characterization, and In Vitro Evaluation of Demethoxycurcumin and Bisdemethoxycurcumin-Loaded Nanoparticles
Contributor:
Wilhelm Romero, Krissia;
Quirós, María Isabel;
Vargas Huertas, Felipe;
Vega-Baudrit, José Roberto;
Navarro-Hoyos, Mirtha;
Araya-Sibaja, Andrea Mariela
Published:
MDPI AG, 2021
Published in:
Polymers, 13 (2021) 23, Seite 4207
Language:
English
DOI:
10.3390/polym13234207
ISSN:
2073-4360
Origination:
Footnote:
Description:
Polymeric lipid hybrid nanoparticles (PLHNs) are the new generation of drug delivery systems that has emerged as a combination of a polymeric core and lipid shell. We designed and optimized a simple method for the preparation of Pluronic F-127-based PLHNs able to load separately demethoxycurcumin (DMC) and bisdemethoycurcumin (BDM). CUR was used as a model compound due to its greater availability from turmeric and its structure similarity with DMC and BDM. The developed method produced DMC and BDM-loaded PLHNs with a size average of 75.55 ± 0.51 and 15.13 ± 0.014 nm for DMC and BDM, respectively. An FT-IR analysis confirmed the encapsulation and TEM images showed their spherical shape. Both formulations achieved an encapsulation efficiency ≥ 92% and an exhibited significantly increased release from the PLHN compared with free compounds in water. The antioxidant activity was enhanced as well, in agreement with the improvement in water dissolution; obtaining IC50 values of 12.74 ± 0.09 and 16.03 ± 0.55 for DMC and BDM-loaded PLHNs, respectively, while free curcuminoids exhibited considerably lower antioxidant values in an aqueous solution. Hence, the optimized PHLN synthesis method using CUR as a model and then successfully applied to obtain DMC and BDM-loaded PLHNs can be extended to curcuminoids and molecules with a similar backbone structure to improve their bioactivities.