Description:
11b,17a,21-Trihydroxypregn-4-ene-3,20-dione or cortisol (C21H30O5) represents the product of adrenal glands and in humans its assessment is a useful tool for evaluation of glucocorticoid axes. Our purpose is to evaluate the profile of morning plasma cortisol/ACTH/ionogram in menopausal women with non-functioning adrenal tumours. A controlled study of 193 menopausal women found that BMI is statistically significant higher versus control in subjects with unilateral, respective bilateral adrenal non-secretor tumours. Baseline C21H30O5 is similar between the groups while ACTH is decreased when compare with control group indicating a potential persistent cortisol tumour-related exposure. Glycated haemoglobin A1c is increased in group with single adrenal mass (versus control) while serum sodium is higher in group with double adrenal masses (versus control).