Description:
<jats:p>BACKGROUND: Extubation failure of patients on mechanical ventilation is relatively a frequent finding in the intensive care unit (ICU) and associated with poor prognosis.
AIM: We conducted this study in Critical Care Department, Cairo University hospitals in which we aimed to assess if there is advantage to use high flow nasal cannula (HFNC) or non-invasive ventilation (NIV) over conventional oxygen therapy (COT) in success of extubation of patients.
METHODS: The study included 60 patients and was randomized into three equal groups. The first group used HFNC, the second group used COT, while the third group used NIV. The reintubation rate, ICU stay, ICU mortality, and 28-day mortality were followed in all groups.
RESULTS: The all study population had a mean age of 62 ± 21, 31 patients were male, and 21 patients were smokers. SOFA score on admission, APACHE II, and SOFA pre-extubation was not significantly different in the three groups. Reintubation rate was higher in COT group compared to HFNC or NIV groups (p < 0.05). ICU stay was longer in COT compared to the other two groups, while ICU and 28-day mortality showed no significant difference among the all groups.
CONCLUSION: Use of HFNC and NIV was associated with lower reintubation rate, improved oxygenation and shorter ICU stay but no significant effect on mortality in comparison with COT.</jats:p>