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Media type:
E-Article
Title:
Sodium-Glucose Cotransporter 2 Inhibitors for Chronic Kidney Disease: A Comprehensive Review
Contributor:
Song, Su Hyun;
Bae, Eun Hui
imprint:
Korean Association of Internal Medicine, 2024
Published in:The Korean Journal of Medicine
Language:
English
DOI:
10.3904/kjm.2024.99.2.61
ISSN:
2289-0769;
1738-9364
Origination:
Footnote:
Description:
<jats:p>Chronic Kidney Disease (CKD) is a major global health burden. Sodium-glucose cotransporter-2 (SGLT2) inhibitors have demonstrated potential in slowing CKD progression. We evaluated the expanding role of SGLT2 inhibitors, emphasizing their renoprotective benefits in diabetic and non-diabetic CKD patients. We also investigated the underlying mechanisms, including the reduction of glomerular hypertension via modulation of tubuloglomerular feedback. Our study critically analyzed current indications for SGLT2 inhibitor therapy based on recent clinical trial data. To optimize patient outcomes, we present a comprehensive analysis of practical considerations for the prescription of SGLT2 inhibitors, including the potential initial decline in the estimated glomerular filtration rate and a review of adverse events.</jats:p>