High-Affinity IgE Receptors on Dendritic Cells Exacerbate Th2-Dependent Inflammation

Media type: E-Article

Title: High-Affinity IgE Receptors on Dendritic Cells Exacerbate Th2-Dependent Inflammation

Contributor: Sallmann, Eva; Reininger, Bärbel; Brandt, Sabine; Duschek, Nikolaus; Hoflehner, Elisabeth; Garner-Spitzer, Erika; Platzer, Barbara; Dehlink, Eleonora; Hammer, Martina; Holcmann, Martin; Oettgen, Hans C.; Wiedermann, Ursula; Sibilia, Maria; Fiebiger, Edda; Rot, Antal; Maurer, Dieter

imprint: The American Association of Immunologists, 2011

Language: English

DOI: 10.4049/jimmunol.1003392

ISSN: 0022-1767; 1550-6606

Keywords: Immunology ; Immunology and Allergy

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Footnote:

Description: Abstract The IgE-mediated and Th2-dependent late-phase reaction remains a mechanistically enigmatic and daunting element of human allergic inflammation. In this study, we uncover the FcεRI on dendritic cells (DCs) as a key in vivo component of this form of allergy. Because rodent, unlike human, DCs lack FcεRI, this mechanism could be revealed only by using a new transgenic mouse model with human-like FcεRI expression on DCs. In the presence of IgE and allergen, FcεRI+ DCs instructed naive T cells to differentiate into Th2 cells in vitro and boosted allergen-specific Th2 responses and Th2-dependent eosinophilia at the site of allergen exposure in vivo. Thus, FcεRI on DCs drives the cascade of pathogenic reactions linking the initial allergen capture by IgE with subsequent Th2-dominated T cell responses and the development of late-phase allergic tissue inflammation.

Access State: Open Access

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