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Media type:
E-Article
Title:
Cutting Edge: MicroRNA Regulation of Macrophage Fusion into Multinucleated Giant Cells
Contributor:
Sissons, James R.;
Peschon, Jacques J.;
Schmitz, Frank;
Suen, Rosa;
Gilchrist, Mark;
Aderem, Alan
imprint:
The American Association of Immunologists, 2012
Published in:The Journal of Immunology
Language:
English
DOI:
10.4049/jimmunol.1102477
ISSN:
0022-1767;
1550-6606
Origination:
Footnote:
Description:
<jats:title>Abstract</jats:title>
<jats:p>Cellular fusion of macrophages into multinucleated giant cells is a distinguishing feature of the granulomatous response to inflammation, infection, and foreign bodies (Kawai and Akira. 2011. Immunity 34: 637–650). We observed a marked increase in fusion of macrophages genetically deficient in Dicer, an enzyme required for canonical microRNA (miRNA) biogenesis. Gene expression profiling of miRNA-deficient macrophages revealed an upregulation of the IL-4–responsive fusion protein Tm7sf4, and analyses identified miR-7a-1 as a negative regulator of macrophage fusion, functioning by directly targeting Tm7sf4 mRNA. miR-7a-1 is itself an IL-4–responsive gene in macrophages, suggesting feedback control of cellular fusion. Collectively, these data indicate that miR-7a-1 functions to regulate IL-4–directed multinucleated giant cell formation.</jats:p>