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Media type:
E-Article
Title:
Cutting Edge: Conventional CD8α+ Dendritic Cells Are Preferentially Involved in CTL Priming After Footpad Infection with Herpes Simplex Virus-1
Contributor:
Smith, Christopher M.;
Belz, Gabrielle T.;
Wilson, Nicholas S.;
Villadangos, Jose A.;
Shortman, Ken;
Carbone, Francis R.;
Heath, William R.
imprint:
The American Association of Immunologists, 2003
Description:
<jats:title>Abstract</jats:title>
<jats:p>CTL play a major role in immunity to HSV type 1, but little is known about the priming process. In this study, we have examined the class I-restricted presentation of an immunodominant determinant from HSV-1 glycoprotein B after footpad infection. We have found that the only cell types capable of presenting this determinant in draining popliteal lymph nodes within the first 3 days after infection are the CD11c+CD8α+CD45RA− dendritic cells. Given that such class I-restricted presentation is essential for CTL priming, this implies that these conventional CD8α+ dendritic cells are the key subset involved in CTL immunity to this virus.</jats:p>