You can manage bookmarks using lists, please log in to your user account for this.
Media type:
E-Article
Title:
Cutting Edge: Cross-Regulation by TLR4 and T cell Ig Mucin-3 Determines Sex Differences in Inflammatory Heart Disease
Contributor:
Frisancho-Kiss, Sylvia;
Davis, Sarah E.;
Nyland, Jennifer F.;
Frisancho, J. Augusto;
Cihakova, Daniela;
Barrett, Masheka A.;
Rose, Noel R.;
Fairweather, DeLisa
imprint:
The American Association of Immunologists, 2007
Published in:The Journal of Immunology
Language:
English
DOI:
10.4049/jimmunol.178.11.6710
ISSN:
0022-1767;
1550-6606
Origination:
Footnote:
Description:
<jats:title>Abstract</jats:title>
<jats:p>Recent clinical studies have reinforced the importance of sex-related differences in the pathogenesis of cardiovascular diseases, with an increased incidence and mortality in men. Similar to humans, male BALB/c mice infected with coxsackievirus B3 (CVB3) develop more severe inflammation in the heart even though viral replication is no greater than in females. We show that TLR4 and IFN-γ levels are significantly elevated and regulatory T cell (Treg) populations significantly reduced in the heart of males following CVB3 infection, whereas females have significantly increased T cell Ig mucin (Tim)-3, IL-4 and Treg. Blocking Tim-3 in males significantly increases inflammation and TLR4 expression while reducing Treg. In contrast, defective TLR4 signaling significantly reduces inflammation while increasing Tim-3 expression. Cross-regulation of TLR4 and Tim-3 occurs during the innate and adaptive immune response. This novel mechanism may help explain why inflammatory heart disease is more severe in males.</jats:p>