You can manage bookmarks using lists, please log in to your user account for this.
Media type:
E-Article
Title:
Repressive H3K9me2 protects lifespan against the transgenerational burden of COMPASS activity in C. elegans
Contributor:
Lee, Teresa Wei-sy;
David, Heidi Shira;
Engstrom, Amanda Kathryn;
Carpenter, Brandon Scott;
Katz, David John
imprint:
eLife Sciences Publications, Ltd, 2019
Published in:eLife
Language:
English
DOI:
10.7554/elife.48498
ISSN:
2050-084X
Origination:
Footnote:
Description:
<jats:p>In Caenorhabditis elegans, mutations in WDR-5 and other components of the COMPASS H3K4 methyltransferase complex extend lifespan and enable its inheritance. Here, we show that wdr-5 mutant longevity is itself a transgenerational trait that corresponds with a global enrichment of the heterochromatin factor H3K9me2 over twenty generations. In addition, we find that the transgenerational aspects of wdr-5 mutant longevity require the H3K9me2 methyltransferase MET-2, and can be recapitulated by removal of the putative H3K9me2 demethylase JHDM-1. Finally, we show that the transgenerational acquisition of longevity in jhdm-1 mutants is associated with accumulating genomic H3K9me2 that is inherited by their long-lived wild-type descendants at a subset of loci. These results suggest that heterochromatin facilitates the transgenerational establishment and inheritance of a complex trait. Based on these results, we propose that transcription-coupled H3K4me via COMPASS limits lifespan by encroaching upon domains of heterochromatin in the genome.</jats:p>