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Media type:
E-Article
Title:
Self-organized patterning of cell morphology via mechanosensitive feedback
Contributor:
Dye, Natalie A;
Popović, Marko;
Iyer, K Venkatesan;
Fuhrmann, Jana F;
Piscitello-Gómez, Romina;
Eaton, Suzanne;
Jülicher, Frank
imprint:
eLife Sciences Publications, Ltd, 2021
Published in:eLife
Language:
English
DOI:
10.7554/elife.57964
ISSN:
2050-084X
Origination:
Footnote:
Description:
<jats:p>Tissue organization is often characterized by specific patterns of cell morphology. How such patterns emerge in developing tissues is a fundamental open question. Here, we investigate the emergence of tissue-scale patterns of cell shape and mechanical tissue stress in the <jats:italic>Drosophila</jats:italic> wing imaginal disc during larval development. Using quantitative analysis of the cellular dynamics, we reveal a pattern of radially oriented cell rearrangements that is coupled to the buildup of tangential cell elongation. Developing a laser ablation method, we map tissue stresses and extract key parameters of tissue mechanics. We present a continuum theory showing that this pattern of cell morphology and tissue stress can arise via self-organization of a mechanical feedback that couples cell polarity to active cell rearrangements. The predictions of this model are supported by knockdown of MyoVI, a component of mechanosensitive feedback. Our work reveals a mechanism for the emergence of cellular patterns in morphogenesis.</jats:p>