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Media type:
E-Article
Title:
An Experimental Study of the Pathogenesis of Fowlpox Infection in Chickens
Contributor:
Minbay, Ahmet;
Kreier, Julius P.
imprint:
American Association of Avian Pathologists, Inc., 1973
Published in:Avian Diseases
Language:
English
ISSN:
0005-2086;
1938-4351
Origination:
Footnote:
Description:
<p>The pathogenesis of experimental fowlpox in chickens infected with various strains of the virus by the intradermal, intravenous, and intratracheal routes was studied. The various strains all caused diseases which developed similarly if given by the same route. The clinical features of the disease produced were influenced more by route of infection than by the strain used. Lesions developed only at the site of injury when virus was given intradermally. Virus was not detected in the blood or internal organs of any of the 80 chickens infected intradermally. Lesions developed on many sites when infection was by the intravenous route. The disease in intravenously infected chickens was severe. Five of them died of the disease between the 13th and 18th days after inoculation and others would have if they had not first been killed for sample collection. Virus was detected in the liver, spleen, kidney, and lung but not in the brain. During the viremic stage, virus was detected only in the buffy coat portion of the blood. No lesions developed in chickens infected intratracheally. Virus was detected in the lungs of these birds but not in other organs. Growth curves of virus in tissues and organs were determined by the titration of samples on chorioallantoic membranes of 12-day-old developing chick embryos.</p>