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Media type:
E-Article
Title:
Expression of M-Cadherin, a Member of the Cadherin Multigene Family, Correlates with Differentiation of Skeletal Muscle Cells
Contributor:
Donalies, Michael;
Cramer, Matthias;
Ringwald, Martin;
Starzinski-Powitz, Anna
Published:
National Academy of Sciences of the United States of America, 1991
Published in:
Proceedings of the National Academy of Sciences of the United States of America, 88 (1991) 18, Seite 8024-8028
Language:
English
ISSN:
0027-8424
Origination:
Footnote:
Description:
Cadherins, a multigene family of transmembrane glycoproteins, mediate Ca2+-dependent intercellular adhesion. They are thought to be essential for the control of morphogenetic processes, including myogenesis. Here we report the identification and characterization of the cDNA of another member of the cadherin family, M-cadherin (M for muscle), from differentiating muscle cells. The longest open reading frame of the cDNAs isolated contains almost the entire coding region of the mature M-cadherin as determined by sequence homology to the known cadherins. M-cadherin mRNA is present at low levels in myoblasts and is upregulated in myotube-forming cells. In mouse L cells (fibroblasts), M-cadherin mRNA is undetectable. This expression pattern indicates that M-cadherin is part of the myogenic program and may provide a trigger for terminal muscle differentiation.