You can manage bookmarks using lists, please log in to your user account for this.
Media type:
E-Article
Title:
Long-Term Synaptic Transformation of Hippocampal CA1 γ-Aminobutyric Acid Synapses and the Effect of Anandamide
Contributor:
Collin, Carlos;
Devane, William A.;
Dahl, Dennis;
Lee, Chang-Joong;
Axelrod, Julius;
Alkon, Daniel L.
imprint:
National Academy of Sciences of the United States of America, 1995
Published in:Proceedings of the National Academy of Sciences of the United States of America
Language:
English
ISSN:
0027-8424
Origination:
Footnote:
Description:
<p>Evidence is presented for a distinctive type of hippocampal synaptic modification [previously described for a molluscan γ-aminobutyric acid (GABA) synapse after paired pre- and postsynaptic excitation]: transformation of GABA-mediated synaptic inhibition into synaptic excitation. This transformation persists with no further paired stimulation for 60 min or longer and is termed long-term transformation. Long-term transformation is shown to contribute to pairing-induced long-term potentiation but not to long-term potentiation induced by presynaptic stimulation alone. Further support for such mechanistic divergence is provided by pharmacologic effects on long-term transformation as well as these two forms of long-term potentiation by Cl<sup>-</sup>channel blockers, glutamate and GABA antagonists, as well as the endogenous cannabinoid ligand anandamide.</p>