You can manage bookmarks using lists, please log in to your user account for this.
Media type:
E-Article
Title:
Gene Deletion of Inositol Hexakisphosphate Kinase 1 Reveals Inositol Pyrophosphate Regulation of Insulin Secretion, Growth, and Spermiogenesis
Contributor:
Bhandari, Rashna;
Juluri, Krishna R.;
Resnick, Adam C.;
Snyder, Solomon H.
imprint:
National Academy of Sciences, 2008
Published in:Proceedings of the National Academy of Sciences of the United States of America
Language:
English
ISSN:
0027-8424
Origination:
Footnote:
Description:
<p>Inositol pyrophosphates, also designated inositol diphosphates, possess high-energy β-phosphates that can pyrophosphorylate proteins and regulate various cellular processes. They are formed by a family of inositol hexakisphosphate kinases (IP6Ks). We have created mice with a targeted deletion of IP6K1 in which production of inositol pyrophosphates is markedly diminished. Defects in the mutants indicate important roles for IP6K1 and inositol pyrophosphates in several physiological functions. Male mutant mice are sterile with defects in spermiogenesis. Mutant mice are smaller than wild-type despite normal food intake. The mutants display markedly lower circulating insulin.</p>