> Details

Cole, Jason M.; Symes, Daniel R.; Lopes, Nelson C.; Wood, Jonathan C.; Poder, Kristjan; Alatabi, Saleh; Botchway, Stanley W.; Foster, Peta S.; Gratton, Sarah; Johnson, Sara; Kamperidis, Christos; Kononenko, Olena; De Lazzari, Michael; Palmer, Charlotte A. J.; Rusby, Dean; Sanderson, Jeremy; Sandholzer, Michael; Sarri, Gianluca; Szoke-Kovacs, Zsombor; Teboul, Lydia; Thompson, James M.; Warwick, Jonathan R.; Westerberg, Henrik; Hill, Mark A.; [...]

High-resolution μCT of a mouse embryo using a compact laser-driven X-ray betatron source

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  • Media type: E-Article
  • Title: High-resolution μCT of a mouse embryo using a compact laser-driven X-ray betatron source
  • Contributor: Cole, Jason M.; Symes, Daniel R.; Lopes, Nelson C.; Wood, Jonathan C.; Poder, Kristjan; Alatabi, Saleh; Botchway, Stanley W.; Foster, Peta S.; Gratton, Sarah; Johnson, Sara; Kamperidis, Christos; Kononenko, Olena; De Lazzari, Michael; Palmer, Charlotte A. J.; Rusby, Dean; Sanderson, Jeremy; Sandholzer, Michael; Sarri, Gianluca; Szoke-Kovacs, Zsombor; Teboul, Lydia; Thompson, James M.; Warwick, Jonathan R.; Westerberg, Henrik; Hill, Mark A.; [...]
  • imprint: National Academy of Sciences, 2018
  • Published in: Proceedings of the National Academy of Sciences of the United States of America
  • Language: English
  • ISSN: 0027-8424; 1091-6490
  • Origination:
  • Footnote:
  • Description: <p>In the field of X-ray microcomputed tomography (μCT) there is a growing need to reduce acquisition times at high spatial resolution (approximate micrometers) to facilitate in vivo and high-throughput operations. The state of the art represented by synchrotron light sources is not practical for certain applications, and therefore the development of high-brightness laboratory-scale sources is crucial. We present here imaging of a fixed embryonic mouse sample using a compact laser–plasma-based X-ray light source and compare the results to images obtained using a commercial X-ray μCT scanner. The radiation is generated by the betatron motion of electrons inside a dilute and transient plasma, which circumvents the flux limitations imposed by the solid or liquid anodes used in conventional electron-impact X-ray tubes. This X-ray source is pulsed (duration &lt;30 fs), bright (&gt;10<sup>10</sup> photons per pulse), small (diameter &lt;1 μm), and has a critical energy &gt;15 keV. Stable X-ray performance enabled tomographic imaging of equivalent quality to that of the μCT scanner, an important confirmation of the suitability of the laser-driven source for applications. The X-ray flux achievable with this approach scales with the laser repetition rate without compromising the source size, which will allow the recording of high-resolution μCT scans in minutes.</p>
  • Access State: Open Access