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Povolotsky, Jacob; Gold, Jonathan W. M.; Chein, Nancy; Baron, Penny; Armstrong, Donald

Differences in Human Immunodeficiency Virus Type 1 (HIV-1) Anti-p24 Reactivities in Serum of HIV-1-Infected and Uninfected Subjects: Analysis of Indeterminate Western Blot Reactions

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  • Media type: E-Article
  • Title: Differences in Human Immunodeficiency Virus Type 1 (HIV-1) Anti-p24 Reactivities in Serum of HIV-1-Infected and Uninfected Subjects: Analysis of Indeterminate Western Blot Reactions
  • Contributor: Povolotsky, Jacob; Gold, Jonathan W. M.; Chein, Nancy; Baron, Penny; Armstrong, Donald
  • imprint: University of Chicago Press, 1991
  • Published in: The Journal of Infectious Diseases
  • Language: English
  • ISSN: 0022-1899
  • Keywords: Major Articles
  • Origination:
  • Footnote:
  • Description: <p>Anti-p24 reactions in sera from 42 human immunodeficiency virus type 1 (HIV-l)-infected and 36 uninfected people with indeterminate Western blot antibody tests for HIV-1 were studied. Anti-p24 reactivity in HIV-1-infected people was completely blocked by HIV-1 recombinant p24 antigen, whereas the reaction in uninfected individuals with indeterminate patterns was inhibited partly or not at all. In contrast to infected individuals, anti-p24 reactivity from uninfected individuals could not be detected by an inhibition ELISA for HIV-1 p24 antibody. These results suggest a practical way to distinguish anti-p24 reactivity in sera from patients with HIV-1 infection from that seen in uninfected patients with indeterminate Western blot reactions.</p>