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Media type:
E-Article
Title:
Transforming Growth Factor type β Induces Monocyte Chemotaxis and Growth Factor Production
Contributor:
Wahl, Sharon M.;
Hunt, Denise A.;
Wakefield, Lalage M.;
McCartney-Francis, Nancy;
Wahl, Larry M.;
Roberts, Anita B.;
Sporn, Michael B.
imprint:
National Academy of Sciences of the United States of America, 1987
Published in:Proceedings of the National Academy of Sciences of the United States of America
Language:
English
ISSN:
0027-8424
Origination:
Footnote:
Description:
<p>Recent studies have focused on the potential role of transforming growth factor type β (TGF-β ) as an immunoregulatory peptide. In this context, we demonstrate that TGF-β is a potent chemoattractant for human peripheral blood monocytes. At concentrations from 0.1 to 10 pg/ml, TGF-β induces directed monocyte migration in vitro. Consistent with this observation is the expression of high-affinity TGF-β receptors on the monocytes with a Kd of 1-10 pM. At higher concentrations of TGF-β (≥ 1 ng/ml), monocytes are stimulated to generate biologically active mediator(s) that enhance fibroblast growth. Gene expression for one of these growth factors, interleukin 1, is induced in monocytes within hours after exposure to TGF-β . Thus, TGF-β may provide an important signal for monocyte recruitment and for regulation of their synthesis of mediators of fibroblast growth and activity in wound healing.</p>