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Media type:
E-Article
Title:
Effect of Cortisone on the Establishment of Nippostrongylus brasiliensis in the Rabbit
Contributor:
Harley, John P.;
Gallicchio, Vincent
Published:
American Society of Parasitologists, 1970
Published in:
The Journal of Parasitology, 56 (1970) 2, Seite 271-276
Language:
English
ISSN:
0022-3395;
1937-2345
Origination:
Footnote:
Description:
The present investigation has shown that neither the cortisone- nor saline-treated rabbit is a satisfactory host for the maintenance of Nippostrongylus brasiliensis. In the saline-treated rabbit, this is due primarily to an inflammatory reaction that occurs in the skin and leads to subsequent nodulation of the infective larvae. Cortisone did suppress the rabbit's inflammatory skin response and a greater number of larvae were able to complete the skin-lung and lung-intestine migrations and become established as adults. However, the majority of larvae recovered from the lungs had failed to undergo the third molt and there was an extension of the worm prepatent period. In addition, other factors (undetermined) appear to prevent the larvae from undergoing normal development in the skin and lungs. There was no stunting of adult worms in the intestine of the rabbit and eggs recovered from feces were viable. Male worms were more numerous than females over a 10-day period postinfection.