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Media type:
E-Article
Title:
Collagen Content of Lungs of Mice after X-Ray Irradiation
Contributor:
Law, Marilyn P.;
Hornsey, Shirley;
Field, Stanley B.
imprint:
Academic Press, Inc., 1976
Published in:Radiation Research
Language:
English
ISSN:
0033-7587;
1938-5404
Origination:
Footnote:
Description:
<p>To investigate the development of late radiation fibrosis in lungs large single doses of X rays were given to the hemithoraxes of mice. Hydroxyproline, an amino acid specific to collagen, was estimated in both irradiated and shielded lungs up to 48 weeks after exposure. There was a dose dependent atrophy of the irradiated lung and a compensatory hypertrophy of the shielded lung. The hydroxyproline per gram of dry irradiated lung increased between 24 and 36 weeks after 2000-4000 rad with no further change up to 48 weeks. Both total hydroxyproline content and dry weight of irradiated lungs decreased but after 24 weeks the histological appearance was that of collagen deposition after edema and hyperplasia. It is concluded that collagen deposition occurs at a late stage in the reorganization after radiation injury to mouse lung and is therefore probably not the cause of 80-180 day death after exposure of the whole thorax.</p>