Opitz, Nadine
[VerfasserIn]
;
Valerius, Oliver
[AkademischeR BetreuerIn];
Valerius, Oliver
[Sonstige Person, Familie und Körperschaft];
Krebber, Heike
[Sonstige Person, Familie und Körperschaft]
Analysis of the Asc1p/RACK1 microenvironment in Saccharomyces cerevisiae using proximity-dependent Biotin Identification (BioID) and high-resolution mass spectrometry
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Medientyp:
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Hochschulschrift
Titel:
Analysis of the Asc1p/RACK1 microenvironment in Saccharomyces cerevisiae using proximity-dependent Biotin Identification (BioID) and high-resolution mass spectrometry
Beschreibung:
The conserved ribosome-associated Asc1 protein of Saccharomyces cerevisiae forms a seven bladed β-propeller and binds to the head region of the 40S ribosomal subunit in close proximity to the mRNA exit tunnel. Asc1p is considered a scaffold protein organizing the local microenvironment near the area of translation initiation at the ribosome to link mRNA translation with cellular signaling. In this study, proteins in the direct proximity of Asc1p were discovered with the in vivo protein labeling technique proximity-dependent Biotin IDentification (BioID) in combination with high-resolution m...