Haupt, Luis Peter
[VerfasserIn]
;
Streckfuß-Bömeke, Katrin
[AkademischeR BetreuerIn];
Hoyer-Fender, Sigrid
[Sonstige Person, Familie und Körperschaft];
Lutz, Susanne
[Sonstige Person, Familie und Körperschaft]
Modeling anthracycline-induced cardiotoxicity with patient-specific iPSCs
Beschreibung:
The anthracycline doxorubicin (DOX), one of the most effective chemotherapeutic drugs for the treatment of various cancers, is limited in its clinical applications due to cumulative dose-dependent cardiotoxicity. The mechanisms of anthracycline-induced cardiotoxicity (ACT) and potential risk factors are still not fully understood. There is good evidence that the pathophysiology of ACT is multifactorial. Increased production of reactive oxygen species (ROS), topoisomerase II poisoning, disturbances in calcium signaling and sarcomere disarray are discussed as key pathomechanisms of ACT in car...